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An Injection To Treat Eczema

Dupixent is the brand name of a prescription medication used to treat:

1. Moderate to severe eczema (atopic dermatitis). Prescribed for adults and children 12 years and older when symptoms can’t be controlled with topical prescription drugs (or when those drugs should not be used).

2. Moderate to severe asthma. Prescribed for adults and children 12 years and older with eosinophilic asthma or oral corticosteroid-dependent asthma. Dupixent is used as an add-on maintenance treatment. Rescue inhalers can still be used as needed for asthma attacks or symptoms such as trouble breathing. Dupixent should never be used to treat a sudden asthma attack.

3. Chronic rhinosinusitis with nasal polyps. It’s prescribed for adults whose symptoms are not well controlled. It’s used as an add-on to maintenance treatment.
Dupixent belongs to a class of medications called monoclonal antibodies. These drugs work on a very specific part of your immune system.
Dupixent Facts

Dupixent comes in a single-dose prefilled syringe. It’s given as a subcutaneous injection (under the skin). Dupixent comes in two doses: a 200-mg/1.14-mL solution and a 300-mg/2-mL solution.

For treating moderate to severe eczema and moderate to severe asthma, the first dose is two injections in different areas of your body. After that, you only need one injection every other week. For chronic rhinosinusitis with nasal polyps, treatment is one injection every other week.

Dupixent is available only as a brand-name medication. It’s not currently available in generic form.

Dupixent contains the active ingredient dupilumab.

Drug Effectiveness

Clinical trials have shown Dupixent to be effective in treating eczema, asthma, and chronic rhinosinusitis with nasal polyps.

In a clinical trial for teenagers with moderate to severe eczema, 24% of people saw clearer skin and 37% of people had less itching within a 16-week period. In adults with eczema, clinical trials showed that almost half of people had a 75% improvement in their skin. Between 36% to 39% of people had clear or almost-clear skin at the end of a 16-week period.
In people with asthma ages 12 years and older, clinical trials showed that Dupixent helped prevent severe asthma attacks . It improved people’s breathing, and they didn’t have to use oral corticosteroids as often to relieve asthma symptoms. Oral corticosteroids are medications such as prednisone that are used to treat inflammation.

Chronic rhinosinusitis with nasal polyps
In a 24-week clinical trial, people taking Dupixent saw about a 51% to 59% improvement in nasal congestion. This is compared to a 16% to 18% improvement in people taking a placebo (a treatment without an active drug). Also, 52% of people saw improvement in their sense of smell. Reduced ability to smell is a common side effect of nasal polyps.

FDA Approval

Dupixent was first approved by the Food and Drug Administration (FDA) in 2017 to treat eczema in adults.

In 2018, it was approved as an add-on maintenance therapy to treat moderate to severe asthma that’s classified as eosinophilic or corticosteroid-dependent in adults and in children ages 12 years and older.

In 2019, Dupixent was approved to treat moderate to severe eczema in children ages 12 years and older with symptoms that can’t be controlled by topical prescriptions (or when topical treatments should not be used). Also in 2019, Dupixent was approved as add-on maintenance therapy to treat chronic rhinosinusitis with nasal polyps in adults.

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